My Version

If I were the director of Mice&Men i would pick Tom Cruise to play George. i Pick him becuase he could fallin into the old fashion look and he is also a very good actor. And i would pick  Adam Sandler to play Lennie because he did a great job in The Water Boy! For Curly's wife i would pick Megan Fox becuase she has a flirty look and that would fit in for Curly's wife. i would pic Taylor Launtner to play Curly becuause he is small but buff. He looks like he goes hard just like Curly. Iwould pick George Clooney to play slim because he is older looking and look like a person that get respected alot. i would have the setting of the story to be in Texas because it give it that old cowboy kind of look.